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RESVERATROL
read James South's resveratrol article
As early as the 1920's Dr. Johanna Brandt wrote a book
proclaiming that grapes cured her of cancer. Since then it has been known that
there are several beneficial substances in grapes (wine also of course) that
assist in lowering cholesterol, reduce the risk of heart disease and have
antioxidant abilities.
Resveratrol (chemical formula 3,5,4'-trihydroxy-trans-stilbene)
is mainly found in the skin of young unripe red grapes.
Animal studies suggest that Resveratrol can prevent the
initiation of cancer and can inhibit the promotion and progression of cancer.
It should be noted that another chemical exists within the
grape that is 3,5,4'-trihydroxy-cis-stilbene and that it can also be
called Resveratrol. However the -cis- version is not as active as the -trans-
version that we offer. IAS's trans-Resveratrol is made by DEDI of
Florida, a company synonymous with producing pharmaceuticals and very high
quality supplements regardless of cost. We don't believe there is a better
quality Resveratrol available anywhere than this brand.
Beware of other Resveratrol’s marketed with large capsule
dosages such as 50mg, 200mg or even greater. Pure Resveratrol is a difficult and
hence expensive substance to produce and what is more clinical trials have
normally only used 5,10 or 15mg daily in the trials.
Specifically trans-Resveratrol can help inhibit all
three stages of cancer by:
- Inducing quinone reductase activity, an enzyme that
is capable of detoxifying carcinogens.
- Inhibiting cyclo-oxygenase, a substance that causes the
production of prostaglandins that stimulate tumor growth, suppress
the immune system and activate carcinogens.
- Inducing the expression of nitroblue tetazolium
reduction activity, a marker of non-specific acid esterase activity and
macrophage formation.
Furthermore trans-Resveratrol can inhibit the
development of cardiovascular disease. This is performed through its ability as
an antioxidant to inhibit platelet aggregation and eicosaniod synthesis and its
ability to modulate lipoprotein metabolism.
Resveratrol doses for inhibition (i.e. assistance in the
prevention) of cancer and cardiovascular disease are 5mg or 10mg daily. Doses
for the treatment of the same are 15mg to 30mg daily.
Caution; Anyone who suffers from platelet deficiency or
blood-clotting difficulties or taking blood thinning drugs should only use
Resveratrol under medical supervision.
"Resveratrol inhibits cellular events associated with
tumor initiation, promotion and progression."
M. Jang et. al "Cancer chemo-preventative activity of resveratrol, a
natural product derived from grapes." Science 275, 218-220 (1997)
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