Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.

Bastuji H; Jouvet M

Neurophysiologie Clinique, 
Hospital Neurologique, Lyon, France
Prog Neuropsychopharmacol Biol Psychiatry, 12(5):695-700 1988

Abstract:

1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy.

2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics.

3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them.

4. Modafinil, used for at least 3 years in some patients, produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.

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