Long-term treatment with moclobemide.
An open-label, non-comparative, multiple-distributed study in patients with a major depressive episode as defined by DSM-III.

Moll E, Stabl M, Wegscheider R, Amrein R

Clinical Research Department (PRCT-P)
 F. Hoffmann-La Roche Ltd, Basel, Switzerland.
: Psychopharmacology (Berl) 1992;106 Suppl:S120-2

ABSTRACT

Evaluation of 247 patients receiving long-term moclobemide treatment showed that it was effective as an antidepressant, as measured both by decrease in HAMD mean total score and the doctor's evaluation of therapeutic effect. In patients who had been treated for 6 months or less, results were less favourable (ratings of 'very good' or 'good' in 31.5%, compared with 81.3% in patients treated for more than 6 months). This was due to a higher number of drop-outs, as a result of insufficient efficacy in the first 6 months. In those patients who responded favourably, 9.2% relapsed within 6 months of commencing treatment; of the remaining responders, 16% relapsed during months 7-12. In terms of the doctor's evaluation of side-effects, tolerability was 'very good' or 'good' in 88.2%.

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                Moclobemide research

         1.    Moclobemide  for the treatment of depression
         2.    Moclobemide  in clinical psychopharmacology
         3.    Moclobemide  therapy for chronic depressive disorders 
         4.    Moclobemide  and tranylcypromine in depression
         5.    Moclobemide  and fluoxetine for panic disorder
         6.    Moclobemide  in patients with dementia and depression
         7.    Moclobemide  in mild major depression
         8.    Moclobemide  for depression
         9.    Moclobemide  in treatment of major depressive episodes
        10.   Moclobemide  vs. placebo in the treatment of depression
        11.   Moclobemide  long-term treatment in major depression
        12.   Moclobemide  and sertraline in the treatment of depression
        13.   Moclobemide  in long-term treatment
        14.   Moclobemide  vs fluoxetine for double depression
        15.   Moclobemide  vs fluoxetine in major depressive disorders
        16.   Moclobemide  vs fluoxetine in major depression

 

 

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