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1. Gerovital-H3
its regenerative effects
2. Gerovital-H3 anti-depressant effects
3. Gerovital-H3
creator Ana Aslan's life
4. Gerovital-H3 treatment in osteoarthritis
5. Old
age humoral dismetabolism (GH-3)
6. Gerovital-H3
treatment in rheumatology
7. Gerovital-H3
classic antiaging medicine
Gerovital-H3 treatment in Rheumatology
by Mircea Dumitru M.D., PhD.
to order GH-3
Comparative
studies present certain peculiarities of the human osteoarticular with aging:
osteopeny, degenerative modifications of the intervertebral discs, the reduction
of the osseous capital. The decline of the muscle force, (more evident in men,)
represents a primordial sign of aging and begins to
manifest after the age of 30. The capacity of muscular and osteoarticular
effort requires a longer adaptation period and falls may happen during the
effort.
The normal aging of the osteo–articular
system may be appreciated with the aid of quantitative and qualitative
indicators. The bone involution after the growing period shows that the bone
volume diminishes progressively with the advance in age, with some peculiarities
in women. The psychological osteopenia and the involutive modifications of the
other elements of the osteo–articular system may be accentuated in old people
by protein, calcium and vitamin D deficiency, in various digestive and endocrine
diseases, or due to iatrogenic causes. Age related changes in the joint can be
found in almost all people over 65. Joints become increasingly misshapen. Aging
of cartilage is associated with biochemical modifications. The content of water
decreases, but proteoglycan content remains unchanged, thus undergoing changes.
Metabolical changes in cartilage or changes in joint biomechanics make easier
the development of the osteoarthritis process. By its frequency and
medico-social implications, arthritis and rheumatoid arthritis have an important
place in rheumatology.
Osteoarthritis
Osteoarthritis is the most
common form of arthritis in the elderly. Millions of people suffer from pain,
limitation of motion and disability because of osteoarthritis. There is an
exponential increase in arthritis with advancing age. In the last decades more
adult people are suffering degenerative alterations of joints because of obesity
and lack of physical movement. Is there a relationship between aging and
osteoarthritis?
As I mentioned, aging is
facilitating the development of arthritis, but the normal changes of the bone
and joint are not those of osteoarthritis.
The earliest events in
osteoarthritis occur in the cartilage: decreased total proteoglycan content and
shortening of the glucosaminoglycan branches. The continuity of the surface of
cartilage is disrupted. The most important change in arthritis is the
fibrillation of the cartilage with the focal erosions. In the meantime changes
in subchondral are occurring, leading to an decrease in the density of bone with
a consequent reduction in the mobility of the joint. We do not know the exact
nature of the events that initiate arthritis. Trauma, aging, occupations,
metabolic diseases, life-style and genetic factors cause alterations into the
structure of cartilage that facilitate osteoarthritis. The most common joints
that are affected are the hip, knee, carpometacarpal, and the spine.
The
clinical use of Gerovital-H3
Many studies prove the positive
effect of Gerovital-H3 in arthritis (1,2,3,4,5,6,7,8). I studied 100 subjects
suffering from moderate to severe arthritis admitted to the prophylactic
treatment center at the Nat. Inst. of Gerontology & Geriatrics- Bucharest, 1985 (7). From the
beginning in 1946, Prof. Ana Aslan tried to discover explanations to the complex
biological phenomena with special attention to arthritis. In 1947, Aslan started
administering procaine in cases of trophic troubles of the extremities,
sometimes with spectacular results. This is what she declared;
“After one injection in the
femoral artery, given to a patient with embolism at the level of the inferior
extremity, I noticed the almost instantaneous disappearance of pain. Then, for
the first time, I had the idea to apply the same method in certain diseases with
pain, like rheumatism-specially at the level of knee articulations- which
produces immobilization and thus long-lasting incapacity”.
Later on, Prof. Aslan used that
method of treatment with procaine arterially administered to patient with
arthritis, and she presented the results obtained with the first 50 cases at a
scientific session of the Romanian Academy back in 1950. Starting in 1949, Aslan
started applying procaine treatment in an old people’s home (based on the fact
that such patients present frequent cases of arthritis). Besides an improvement
of the local movement, she noticed an obvious improvement of the physical and
psychological state of the elderly.
She then initiated experimental
arthritis research which evinced particularly favorable effects on animals
treated with procaine. Gerovital-H3 has a positive effect on cell metabolism and
on the cell membrane. There are studies where the emphasis was placed on
Gerovital-H3 intervention on the collagen metabolism in arthritis. Aslan
demonstrated the positive effect of her treatment on experimental arthritis
studies (3). In my career, I've treated thousands people with arthritis all over
the world. I studied one group of elderly people under treatment with
Gerovital-H3 suffering from moderate to severe arthritis involving spine,
peripheral joints, hips and knees (7).
Gerovital-H3 was administered
one injection daily for 18 days followed by 12 days of Gerovital-H3 pills daily.
I assessed the efficacy of the treatment comparing pain, joint mobility,
functional capacity of the joints and muscular tone before and after the
observation. In parallel, I noted the psychic mood and the circadian rhythm of
blood pressure. Clinical symptoms like pain and joint mobility have had a
remarkable alleviation in 34%, respectively in 56% and the muscular tone of the
patients was improved in 41%.
I want to emphasize that during
the Gerovital-H3 treatment no side effects were noted. The beneficial effect of
Gerovital-H3 treatment is due to its antalgo action, an improvement of capillary
permeability and the favorable intervention in the bioenzymatic disorders at the
level of the joint cartilage. Gerovital-H3 can be the drug of choice in the
management of mild clinical arthritis forms and can be administered with non-sterodial
anti-inflammatory drugs (NSAIDs) in severe arthritis.
Preventative
treatment
From the age of 40, we can
start an arthritis’ Preventive Treatment with Gerovital-H3: one course of 25
pills over 12 days (one pill twice daily between the meals) and then a 2 week
break. The cycle is then resumed. It is possible to do a milder prophylactic
treatment only with pills in a series of 25 pills during 12 days with an
interval of 45 days in between.
Curative
treatment
At the beginning of arthritis
or in a clinically advanced form, I recommended Curative Treatment: a course of
1 injection daily for 12-days followed by a 2 week break and then one course of
25 pills over 2 weeks – in total
6 courses of 12 injections and 5 courses of 25 pills-yearly. Gerovital-H3
treatment can be individualized; we can shorten or extend the breaks depending
on the results, arthritis gravity and the accompanying diseases. Taking into
consideration cost-results and side effects, with incipient and mild clinical
form of arthritis, Gerovital-H3 treatment is superior compared to NSAIDs.
Rheumatoid
arthritis
Rheumatoid arthritis (RA) is a
chronic inflammatory arthritis. The clinical features vary widely ranging from a
mild disease to a progressive one. The pattern is influenced by sex, age,
endocrine and genetic factors. RA may begin in the aged, or may be encountered
in an already “old” form, whose symptoms begin in the adult age. The
clinical picture is more faded, often oligosymptomatical.
In many old people, RA is no
longer active and a sick patient presents symptoms and a better prognosis for
seronegative elderly onset. Symptoms such as morning stiffness, fatigue, weight
and appetite loss precede the onset of RA. Usually, the onset of RA afflict
metacarpophalangeal joints and later on may involve hips, knees and shoulders.
Extra-articular symptoms are rare in old people. At this age we have to
differentiate RA from polymialgia rheumatica, amyloid arthropathy and arthritis.
Gerovital-H3 treatment is
indicated in the incipient stage of RA. Its anti-inflammatory effect is exerted
through the AMPc stimulated by the moderate rise in circulating catecholamine
levels in synovia (5,6). Because RA is a very distressing and an invalidating
disease, Gerovital-H3 with its affects of less fatigue, less stiffness and its
antidepressive effect is beneficial.
Low
back pain
Low back pain afflicts
one out of every four adults and old people. Many of them can not get out of the
bed because of Low Back Pain and they are using anti-inflammatory and pain
killing drugs with many side effects. After surgery within one year 50% to 60%
of the patients will have the same low back and leg pain. The best care of back
pain is the multidisciplinary approach. The loss of disc height is called disc
degeneration and sometimes arthritis. Conservative treatment should be used
before surgery and can be helpful to relieve pains following back surgery.
Gerovital-H3 has a strong
indication in low back pain because of its anti-degenerative effect and to
relieve muscle spasm. Gerovital-H3 is administered locally and I.M. After a
couple of days, the patient is more relaxed and is sleeping better. To help
relieve the pain it is po
ssible to apply Gerovital-H3 into certain points. For maximum results,
the patient has to be treated daily for the first two weeks. Depending on their
condition (arthritis, degenerative disc, spondylolisthesis, sacroiliac treatment
etc.) physical therapy should also be applied to help take away the swelling
that accompanies the ailments.
ALL INFORMATION IS EDUCATIONAL AND
SHOULD NOT REPLACE THE ADVICE OF
YOUR PHYSICIAN.
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