Penicillin-VK

Ingredients
Each sachet contains: Potassium phenoxymethylpenicillin 250 mg (375,000 IU) Excipients: Sucrose, sodium saccharine, essence of banana. (a sachet is a small packet filled with powder that is dissolved in water immediately before use) 
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Properties
Potassium penicillin V is the potassium salt of phenoxymethylpenicillin. It provides the advantages of stability in an acidic medium and easy absorption when taken by mouth. It is a bactericide and acts during the period of bacterial multiplication, inhibiting the biosynthesis of the mucopeptide of the cell wall.

The usual dosage produces therapeutic concentrations in different liquids of the organism that base their use on these instructions. 80% combine with plasmatic proteins.

Its activity has been proven, "in vitro" among other methods, with respect to the following microorganisms: Straphylococcus, non-producers of penicillinase, streptococcus (groups A, C, G, H, L and M) and diplococcus pneumoniae.

Indications
Infections produced by penicillin-sensitive germs such as: Infections of the respiratory tract: Tonsillitis, septic pharyngitis, otitis Bronchitis, bronchopneumonia Moderate infections of the skin and soft tissues: Scarlet fever, erysipelas, boils, abscesses Prophylaxis of rheumatic fever and bacterial endocarditis In orthodontic problems: Gumboils, stomatitis, gingivitis, prophylaxis of infections in tooth extractions.

N.B. Penicillin is the medicine of choice in the treatment and prophylaxis of streptococcal infections, including prophylaxis of rheumatic fever.

Dosage
The dosage should be established depending on the sensitivity of the causal germ and the seriousness of the infection, and should be modified according to the clinical response of the patient.

Children:
In general, 50 mg/kg of body weight (75,000 IU/kg) per day, taken in 2 or 3 doses.

• For treatment of streptococcal infections, the following is recommended:
• For children of 1 to 5 years of age: one sachet (250 mg) every 8 hours or 2 sachets (500 mg) every 12 hours for 10 days.
• For children of 6 to 12 years of age: two sachets (500 mg) every 8 hours for 10 days.
• In prophylaxis of rheumatic fever or bacterial endocartitis, one sachet (250 mg) every 12 hours.
• For children over 12 years of age: the usual adult dosage.

Adults:
For streptococcal and staphylococcal infections: 2 sachets (500 mg) every 6-8 hours for 10 days.

• Necrotic gingivitis: 2 sachets (500 mg) every 6-8 hours.
• In prophylaxis of rheumatic fever or glomarulonephritis: 1-2 sachets (250-500 mg) every 12 hours.
• In any infection caused by haemolytic streptococcal treatment should last at least 10 days to avoid the appearance of acute rheumatic fever and glomerulonephritis.

Directions For Use
Pour the contents of the sachet into 20 ml of water. Shake until completely dissolved.

PENILEVEL 250 mg can be taken with meals. Nevertheless, the plasmatic levels are slightly higher when taken on an empty stomach.

Contraindications
Patients with case histories involving sensitivity to penicillin.

Precautions
This product should be taken with caution by patients allergic to cephalosporins and those with a previous history of allergies to medicines.

Treatment should be stopped if any allergic reaction should be noticed.

Warning
Concerning excipients: "Patients with a hereditary intolerance to fructose, problems with glucose/galactose, a saccharase-isomaltase deficiency and diabetics should bear this in mind that this medicine contains 4.5 g of sucrose per sachet".

Interactions
This pharmaceutical product should not be taken simultaneously with bacteriostatic antibiotics. The probenecid reinforces its action by diminishing its tubular secretion.

Adverse Effects
Allergic reactions may occur such as urticaria and erythematic rash. Gastrointestinal alterations may also take place (nausea, vomiting, diarrhoea).

Reversible haematic alternations (anaemia, thrombocytopenia, leucopenia, coagulation disorders.

Intoxication And Its Treatment
The toxicity level of PENILEVEL 250 mg is very low. In the event of an allergic reaction, treatment should be stopped and a specific therapeutic product administered (corticosteroids, antihistamines, oxygen therapy, etc).

Available In
Box of 12 250-mg sachets Box of 24 250-mg sachets

KEEP THIS AND ALL OTHER MEDICINES SAFELY OUT OF THE REACH OF CHILDREN.

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